The combination of the MCC with CCS or SSG resulted in substantial
increases to more than 5.0% free salicylic acid overall, so failed to
meet the USP requirements. Again, the most acceptable results were seen
for tablets containing MCC and P-PGS as the
uggs boots,
which showed no increase in free salicyclic acid when desiccant was
used and only a 0.91% increase when packaged without desiccant. The
addition of P-PGS substantially reduced the amount of ASA degradation in
those tablets containing MCC combined with either SSG or CCS, which had
unacceptable free salicylic acid levels.
It was interesting to note that the addition of desiccant packs to the
bottles was not sufficient to eliminate, or even substantially reduce,
the adverse effects of the superdisintegrants. Of the six formulations,
the tablets containing MCC alone or the
ugg boots
excipient combination met the desired stability performance
requirements of good appearance, acid resistance and acceptable free
salicylic acid levels. The formulation with just MCC did not meet the
delayed dissolution requirements for ASA release in buffer either
initially or after 3 months of storage, in accelerated conditions. The
tablets containing the MCC-P-PGS combination did exhibit excellent
delayed release dissolution results initially and after 3 months at 40
degrees north face denali.
The results obtained in this study have yielded a relatively simple ASA
formulation utilizing a combination of MCC and P-PGS as the primary
uggs boots
excipients. MCC in the formulation provides that compactability needed
for producing a tablet that will withstand the mechanical stresses of
the film-shoeing process.
Par
golfs le mardi 26 juillet 2011
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